TNF and neoplasm: One of the identified programs (Program-1) includes factors such as the IL2 level in the tumor, the amount of Treg on the Tumor-draining Lymph node (TDLN), TNFa in the Tumor, Neutrophils in the Tumor, naïve CD8 + T cells in the Tumor, Activated CD8 + T cells in the Tumor, TNFa in the General Lymph Nodes, Activated B cells in Tumor Draining Lymph Nodes, Neutrophils Extracellular Traps (NETs) in the Tumor, and Long-lived plasma (antibody-secreting) B cells (PL) in Tumor Draining Lymph Nodes (Fig 3B).