This cluster included enrichment in pathways like MAPK phosphatase activity (log10(P) = −15.3043), where the cell adhesion molecule CTNNA1 was found to interact with SARS-CoV-2 Orf7b protein and to be phosphorylated in response to infection, or arachidonate production (log10(P) = −16.7445), where the alcohol dehydrogenase AKR1A1 was found to support SARS-CoV-2 replication and to interact with Orf3 (Fig 2B—right). The gene discussed is AKR1A1; the disease is infection.