OBSL1 and infection: Interestingly, we found enrichment in pathways not found by previous CRISPR screens, including MAPK phosphatase activity, where the adhesion molecule CTNNA1 was found to be phosphorylated during infection and to interact with Orf7b, as well as factors not previously reported, including the calcium-dependent endopeptidases OBSL1 and MYL1, found in network with SARS-CoV-2 M protein (Fig 2B).