As shown in Fig 4, genes (CTCFL, PLAC1, LEMD1, PRAME, CEP55, DKKL1, PBK, ATAD2, and TTK) from the GEPIA2 dataset, and genes (PLAC1, FBXO39, LEMD1, DKKL1, PBK, ATAD2, and TTK) of primary and recurrent GBM from the mRNA_seq693 of the CCGA cohort were not associated significantly with OS in GBM patients. The gene discussed is PRAME; the disease is glioblastoma.