In myocardial ischaemia-reperfusion injury, miR-30a-5p exacerbates myocardial damage through the circ_0002612/miR-30a-5p/Ppargc1a/NLRP3 axis, while its inhibition can enhance mitochondrial function by activating SIRT1 [47–49]. The gene discussed is SIRT1; the disease is injury.