Moreover, mutant-EZH2 was shown to maintain the GC phenotype in DLBCL, potentially by mediating a significant increase in bivalent nucleosomes, marked by both the repressive H3K27me3 and the active tri-methylation of lysine 4 on histone H3 (H3K4me3) [27,28,35]. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.