PLOD2 and lymphangioleiomyomatosis: Utilizing snRNA-seq of LAM tissue, we found that exogenous EP treatment of WT mice leads to similar changes in the transcriptional signature of LAM fibroblasts that contribute to LAM fibrosis, including upregulation of several profibrotic genes (e.g., Zbtb16, Sfrp4, and Plod2) (37, 43).