Additionally, inferred motif activity of the TGF-β downstream transcription factors Smad2 and Smad3 was increased in EP LAM compared with Veh and EPR LAM in Pgr– fibroblasts and mesothelial-like cells (Supplemental Figure 7, C and D) (42). The gene discussed is TGFB1; the disease is lymphangioleiomyomatosis.