To determine the mechanisms through which P4/PGR signaling causes LAM fibrosis, muscle atrophy, and hernia development, we performed snRNA-seq of the LAM of WT mice after 10 weeks of treatment with Veh, EP, and E2 plus P4 plus RU486 (EPR) (Supplemental Figure 3A). This evidence concerns the gene PGR and lymphangioleiomyomatosis.