EGFR and lymphangioleiomyomatosis: Pathway analysis of EP LAM revealed enrichment of genes involved in TGF-β receptor (TGFBR), platelet-derived growth factor receptor (PDGFR), epidermal growth factor receptor (EGFR), and interleukin-6–mediated (IL-6–mediated) signaling, suggesting that at the overall tissue level, EP LAM is more proinflammatory and profibrotic compared with Veh and EPR LAM (Supplemental Figure 4D).