To determine the mechanisms through which P4/PGR signaling causes LAM fibrosis, muscle atrophy, and hernia development, we performed snRNA-seq of the LAM of WT mice after 10 weeks of treatment with Veh, EP, and E2 plus P4 plus RU486 (EPR) (Supplemental Figure 3A). The gene discussed is PGR; the disease is Hernia.