Pathway analysis of EP LAM revealed enrichment of genes involved in TGF-β receptor (TGFBR), platelet-derived growth factor receptor (PDGFR), epidermal growth factor receptor (EGFR), and interleukin-6–mediated (IL-6–mediated) signaling, suggesting that at the overall tissue level, EP LAM is more proinflammatory and profibrotic compared with Veh and EPR LAM (Supplemental Figure 4D). This evidence concerns the gene IL6 and lymphangioleiomyomatosis.