B2M and hepatocellular carcinoma: Wnt/b-catenin driven immune exclusion in HCC is thought to involve the downregulation of chemokines driving dendritic cells and lymphocyte chemotaxis such as CCL4 and CCL5, as well as the epigenetic repression of genes implicated in antigen type I presentation like B2M, HLA-B and HLA-C [104].