The expression of some of these genes within this 118 gene signature, such as DNMT1, UHRF1, EHMT2, EZH2, ATAD2, SMYD3, CBX4, SMARCA4, SMARCA2 and KDM8 has been previously reported to be altered in HCC [7, 42, 46, 55, 81, 114, 137], which confirms the accuracy of our findings. Here, SMYD3 is linked to hepatocellular carcinoma.