SOAT1 and asthma: Among the genes featured in this network, we again find several linked to allergic inflammation: SUZ12 inhibition is associated with the reduction of allergic inflammation through is role in the protein complex PRC2, JAK2 inhibitors have been proposed to alleviate asthma because of JAK2’s role in the JAK-STAT signaling pathway, and knockdown of MYC has been shown to repress ILC2 (type 2 innate lymphoid cell, a type of immune cell) activity, which in turn reduced airway inflammation and immune hyperresponsiveness (53, –55).