Functional experiments using FTH1‐knockdown/−overexpressing HCC cell lines and xenograft models demonstrated that FTH1 enhances proliferation, migration, and tumour growth by upregulating CYP1A1/CYP1A2 in the tryptophan pathway, thereby increasing the synthesis of 6‐hydroxymelatonin (6‐HMT). This evidence concerns the gene CYP1A2 and hepatocellular carcinoma.