In this study, we investigated two strategies for the generation of CD8+ T cells from hiPSCs expressing a T cell receptor (TCR) specific for the melanoma‐associated antigen recognized by T cells (MART‐1) or a chimeric antigen receptor (CAR) specific for the melanoma‐associated chondroitin sulfate proteoglycan (MCSP), respectively. The gene discussed is CD8A; the disease is melanoma.