IFNG and respiratory tract infectious disorder: It is therefore striking that here we observed a marked impairment in cDC1s, revealing them to be reduced in frequency in CPA patients’ leukocytes relative to bronchiectasis controls, as has been noted in other respiratory infections including SARS-CoV-2 [25–27] and Influenza A [28], but also impaired in their ability to up-regulate maturation markers and produce IL-12p40, a potent inducer of IFNγ production in T cells, following stimulation with ZYM.