For example, infections with pseudorabies virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), respiratory syncytial virus, influenza A virus (IAV), and Streptococcus induce GSDMD-mediated pyroptosis to elevate the release of proinflammatory cytokines (22, 28, –, 34). The gene discussed is GSDMD; the disease is infection.