Our study revealed that PDCoV infection can trigger GSDME-mediated pyroptosis through the activation of caspase-3, a mechanism also observed in infections with many other viruses, such as SARS-CoV-2, HCoV-229E, ZIKV, IAV, and EV71 (35, –, 37, 39, –, 41). The gene discussed is GSDME; the disease is infection.