THUMPD2 and pancreatic neoplasm: For instance, RHNO1, a protein that promotes homologous recombination repair and is frequently upregulated in breast, liver, and pancreatic cancers, supports tumor cell survival and chemoresistance (45), while THUMPD2 is an RNA-binding protein catalyzing N2-methylation of U6 small nuclear RNA and regulating mRNA splicing (46), and has been shown to regulate ovarian cancer progression, cell migration, and invasion (47).