For instance, RHNO1, a protein that promotes homologous recombination repair and is frequently upregulated in breast, liver, and pancreatic cancers, supports tumor cell survival and chemoresistance (45), while THUMPD2 is an RNA-binding protein catalyzing N2-methylation of U6 small nuclear RNA and regulating mRNA splicing (46), and has been shown to regulate ovarian cancer progression, cell migration, and invasion (47). Here, RHNO1 is linked to familial pancreatic carcinoma.