Moreover, the combination of CD8+ T cells with MK-8722 increased the inhibition of infection in a dose-dependent manner (50% ± 3% and 71% ± 4% inhibition in the presence of CD8+ T cells and 2.5 or 5 μM MK-8722, respectively) compared to the inhibition of infection in the sole presence of CD8+ T cells (19.8% ± 5% ANOVA: P < 0.0001 both, respectively) and in the presence of MK-8722 only (32% ± 3% and 54% ± 6% in the presence of 2.5 or 5 μM MK-8722, t-test P < 0.05 and ns for 2.5 and 5 μM, respectively), although no synergy was observed. The gene discussed is CD8A; the disease is infection.