ULK1 and infection: While neither MK-8722 nor SARS-CoV-2 infection alone affected ULK1 phosphorylation (with the exception of Calu-3 cells, non-infected but treated, where the increase reached 1 ± 0.2 Log2[FC], P < 0.01), MK-8722 treatment during infection was associated with an increase in ULK1 S555 phosphorylation in both cell types (from 0.05 ± 0.5 to 2.8 ± 1.2 Log2[FC] in Vero76 cells and from −0.9 ± 0.5 to 1.3 ± 0.6 Log2[FC] in Calu-3 cells, t-test: ns and P < 0.05, respectively; Fig. 3A and B; Fig. S3A).