MAPT and Alzheimer disease: 2020). Neuropathological hallmarks of AD are amyloid plaque generated from the accumulation of amyloid‐β (Aβ) peptides, neurofibrillary tangles (NFTs) caused by tau hyperphosphorylation, and neural loss (Li, Gui et al. 2020). Inflammation caused by microglia plays an important role in AD pathogenesis (Hansen et al. 2018).