In addition, p‐serine 312‐IRS‐1 and p‐pan‐tyrosine‐IRS1 were shown to be different 1 and 10 years before diagnosis, indicating p‐serine 312‐IRS‐1 and p‐pan‐tyrosine‐IRS1 molecules can be used as differential diagnoses and as predictive biomarkers for AD (Kapogiannis et al. This evidence concerns the gene IRS1 and Alzheimer disease.