FOLH1 and posterior cortical atrophy: The reduction of the S-S bond by glutathione-disulfidereductase (GSR) (Figure ) within the endosomes releases the toxophore inside the cancer cells.In 2009, Kularatne et al. developed a PSMA-targeting bioconjugatefor the diagnostic imaging of PCa (25), (DUPA-Aoc-(Phe)2-Dap-Asp-Cys, A0) (Aoc= aminooctanoic acid, Dap = 2,3-diamino-propanoic acid) (Figure ).