Because MASLD is closely linked to metabolic syndrome and several SNPs that increase the risk of developing MASLD and MASH, we constructed linear models adjusted for body mass index, diabetes status, serum glucose, insulin, total and lipoprotein lipids, and several single nucleotide polymorphism (PNPLA3, TM6SF2, MBOAT7) to assess their effect on FA alterations in patients with MASLD. The gene discussed is PNPLA3; the disease is metabolic syndrome.