Additionally, recent findings suggest that CSF glial reactivity may also be related to sex differences in preclinical Alzheimer’s disease groups.59 Specifically, women showed increased amyloid burden and CSF p-tau levels with elevated CSF glial markers, while men with higher tau burden exhibited lower hippocampal volumes with increased CSF glial reactivity. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.