HAVCR2 and precursor B-cell acute lymphoblastic leukemia: In relapsed B-ALL following allogeneic hematopoietic stem cell transplantation (allo-HSCT), increased co-expression of PD-1 and TIM-3 on CD4+ and CD8+ T cells correlated with reduced proliferative capacity, cytokine production, and cytotoxic potential (73).