In addition, the autophagy score was also significantly positively correlated with the apoptosis score and negatively correlated with proliferation-related pathways such as the E2F target and MYC target V1/V2 scores, indicating that CML cell-mediated autophagy may induce apoptosis and inhibit proliferation, again indicating that a lower autophagy score in CML cells may be related to apoptosis resistance and malignant proliferation. This evidence concerns the gene MYC and chronic myelogenous leukemia, BCR-ABL1 positive.