Figures 1C, D show the expression characteristics of 31 DEARGs in CML samples and normal samples, among which CML samples had more downregulated ARGs. The biological functions of the DEARGs included mainly the regulation of autophagy, phagophore assembly site membrane, cysteine-type peptidase activity and cytokine activity (Figure 1E). In addition to autophagy, they are involved in biological pathways such as apoptosis, pathways in cancer, protein processing in the endoplasmic reticulum, PD-L1 expression and the PD-1 checkpoint pathway in cancer, and the HIF-1 signaling pathway (Figure 1F). Here, CD274 is linked to cancer.