Three machine learning algorithms (LASSO, RF, and SVM-RFE) were used for dimensionality reduction, and we identified 11, 11, and 4 variables associated with CML from DEARGs, respectively (Figures 5A–E), including three overlapping diagnostic ARGs (TUSC1, FOXO1, and ATG4A) (Figure 5F). This evidence concerns the gene FOXO1 and chronic myelogenous leukemia, BCR-ABL1 positive.