APOL2 and Hepatic fibrosis: An obvious hypothesis is the role of APOL2 in the release of extracellular vesicles from hepatic stellate cells, which is known to underly liver fibrosis.8, 9, 10 Consistently, several Ras guanosine triphosphate hydrolase–activating proteins and binding proteins, typically linked to vesicular trafficking, are present in APOL2 immunoprecipitates.1