We also demonstrated short-term improvement in liver injury, fat metabolism, and fibrosis as well as long-term improvement in fibrosis and reduction in tumorigenesis in melanocortin-4 receptor-deficient (Mc4r-KO) mice, a model of metabolic dysfunction-associated steatohepatitis (MASH) [5]. The gene discussed is MC4R; the disease is metabolic dysfunction-associated steatohepatitis.