Among the 11 analyzed cases, the signs and symptoms of Kambô intoxication included arrhythmias, dyspnea, nausea, vomiting, diarrhea, abdominal pain, weakness, electrolyte imbalances, psychosis, and seizures, mechanistically attributed to peptide-induced autonomic dysregulation, gastrointestinal hyperstimulation via CCK-A and NK1 receptors, vasodilation and fluid shifts via bradykinin B2 receptors, ADH dysregulation via CRF1 receptor activation, and possible central effects of opioid receptor agonists. This evidence concerns the gene CCKAR and cardiac arrhythmia.