Among the 11 analyzed cases, the signs and symptoms of Kambô intoxication included arrhythmias, dyspnea, nausea, vomiting, diarrhea, abdominal pain, weakness, electrolyte imbalances, psychosis, and seizures, mechanistically attributed to peptide-induced autonomic dysregulation, gastrointestinal hyperstimulation via CCK-A and NK1 receptors, vasodilation and fluid shifts via bradykinin B2 receptors, ADH dysregulation via CRF1 receptor activation, and possible central effects of opioid receptor agonists. The gene discussed is AVP; the disease is cardiac arrhythmia.