Among them, GAD4 “Trouble relaxing” and GAD2 “Uncontrollable worry” had the highest expected influence (EI = 1.15 and 1.14, respectively), and CESD3 “Feeling blue/depressed” was also statistically stronger than most other nodes in the depression and anxiety network (EI =1.07). The gene discussed is GAD2; the disease is depressive symptom measurement.