CD73 is a receptor which catalyses the degradation of ATP to adenosine.73 CD73 is overexpressed in a variety of cancers and plays a crucial role in facilitating tumour growth and metastasis, rendering this receptor as a desirable target for chemotherapeutic intervention.73 Applying a structure-guided approach, Li et al. identified that modifications to the C3′-position and isosteric groups to mimic the phosphodiester groups were critical for potent inhibition of CD73. The gene discussed is NT5E; the disease is cancer.