Using liver histology assessed by Scheuer system, we evaluated the diagnostic performance of PRO‐C3, GP73, and their combination for the presence of liver fibrosis, and compared them with FIB‐4, APRI, Agile 3+, FAST, and LSM in treatment‐naïve CHB patients from two centers. This evidence concerns the gene GOLM1 and Hepatic fibrosis.