In invasive cancers like osteosarcoma, aberrant mitochondrial dynamics can be effectively suppressed by 2‐methoxyestradiol through modulating key regulatory pathways including PGC‐1α, Cyt c oxidase I (COXI), and sirtuin 3 (SIRT3), thereby interrupting cancer stem cell propagation [105]. The gene discussed is PPARGC1A; the disease is cancer.