CYCS and colorectal cancer: This leads to a concentration‐ and time‐dependent increase in the number of senescent and apoptotic cells [127]. Treatment with high‐concentration (>10 μM) RES downregulates SIRT1 expression, enhances p53 acetylation, and elevates the expression of p21, Bax, cytochrome c, and caspase‐3, ultimately inducing apoptosis in colorectal cancer cells [128].