Our data demonstrated that APOE4 BDEVs contain a higher proportion of pS396-Tau+ EVs and higher tau load per EV compared to APOE3 BDEVs, suggesting that APOE4 BDEVs carry pS396-Tau, a marker of neurofibrillary tangle maturation and disease progression5. This evidence concerns the gene MAPT and Neurofibrillary tangles.