When comparing the sex, APOE4/4 BDEVs from female AD cases (E4F-EVs) significantly increased their uptake by MAPTP301L iNeurons, accumulation of pS396 tau level, and MC1 positivity in recipient MAPTP301L iNeurons compared to the rest of the groups (Extended Data Fig. 5d-g). Here, APOE is linked to Alzheimer disease.