In the LMM examining the pre-selected 3 PTSD-relevant ROIs, the group-by-region interactions was significant (F(2,84)=4.49, p=0.014) driving by lower CB1R availability among CT participants in the amygdala (−13.70%, F(1,84)=6.66, p=0.01, d=0.72) and hippocampus (−14.50%, F(1,84)=6.59, p=0.01, d=0.78), but not in the frontal region (−8.08%, F(1,84)=2.17, p=0.14, d=0.47) (Figure1). This evidence concerns the gene CNR1 and post-traumatic stress disorder.