We then tested the ability of Fucoidan-FV to extend healthspan in the Ercc1−/Δ progeria mouse model of accelerated senescence and aging.35 The Ercc1−/Δ mice have reduced ERCC1 expression and thus higher sensitivity to DNA damage, increased accumulation of SnCs, premature aging phenotypes, and 6 fold shorter lifespan.31 Fucoidan-FV was incorporated into the diet at a concentration of 5% and administered ad libitum to male and female Ercc1−/Δ mice over a six week period starting from 10 weeks of age (Fig. 3A). This evidence concerns the gene ERCC1 and progeroid syndrome.