Authors also report that 17% of pregnancies globally and 25% in North America are complicated by obesity.9 Obesity is characterized by a subclinical and chronic inflammatory state that affects several physiological processes including bone metabolism.10 Inflammation may influence BR through the synthesis of adipokines such as IL-6 and TNF-α, which regulate osteoclast activation. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.