PTPRF and psychiatric disorder: In addition, data from gnomAD suggests that PTPRF is evolutionarily constrained as indicated by LOEUF and missense Z scores of 0.35 and 4.05 respectively [75], and as such, the damaging phenotypes elicited by P381L, V389M and P417L could be due to general missense intolerance of PTPRF rather than specific association with psychiatric disorders.