Although the lead SNP in the SYK locus (±50Kb) did not reach genome-wide significance (p=2.1x10−5; Bellenguez et al., 2022), we found a significant association with AD using both GenT and xGenT, with brain eQTLs (p 2x10−9) and pQTLs (p=2.1x10−9). The gene discussed is SYK; the disease is Alzheimer disease.