We identified 26 lead druggable genes (e.g., CHRM5, EGLN1, EZH1, RIOK1, RIPK2, SYK, NTRK1) with significant Bonferroni-adjusted xGenT p-values in eQTL and pQTL analyses that were located outside 1Mb of any of the 82 AD-associated loci (Figure 4b-c). This evidence concerns the gene RIOK1 and Alzheimer disease.