These associations align with observed genetic correlations between gene expression and AD in the cerebellum (RIPK2; Supplementary Figures S16, S33) and hippocampus (RIOK1; Supplementary Figures S15, S32), indicating a potential role for brain expression of RIPK2 and RIOK1 in influencing neuroinflammation associated with AD (Heneka et al., 2015; Mendes et al., 2015; Kaur et al., 2019). The gene discussed is RIOK1; the disease is Alzheimer disease.