Type III IFNs are a known family of antiviral cytokines produced by the placenta that have been shown to limit ZIKV infection of trophoblasts through antiviral gene expression mediated by autocrine signaling.10–12 Notably, our GSEA analysis of bulk RNA-sequencing data revealed similar transcriptional profiles of IL-27- and IFNλ-stimulated trophoblast organoids, with overlapping changes in antiviral gene expression, albeit to differing degrees (Figure 2). The gene discussed is IL27; the disease is Zika virus infectious disease.