IL27 and Zika virus infectious disease: Curiously, one study suggests that placental IFNλ signaling has both protective and pathogenic effects during murine congenital ZIKV infection, depending on the gestational timepoint.28 When pregnant dams were challenged with infection early in pregnancy (E7) IFNλ was pathogenic, whereas IFNλ was protective against infection later in pregnancy (E.9).28 Future studies are needed to explore the possibility of gestational-age dependent effects of IL-27 signaling during congenital murine ZIKV infection.