IL27 and Zika virus infectious disease: IL-27 and IFNλ signaling interplay has been previously described in other contexts, with one study finding that IL-27 can drive IFNλ activation in virus-infected liver cells.27 To directly investigate cytokine signaling interplay in the placenta during congenital infection, future studies could explore ZIKV infection outcomes in the absence of both IL-27 and IFNλ.