Notably, our study12 found that the pharmacological activation of mTOR through oral administration of the mTOR agonist MHY1485 resulted in serine phosphorylation at ATG13 and impaired macroautophagy by dislodging ATG13 from the early autophagy complex, leading to mononucleosis and increased infiltration of inflammatory macrophages in the vasculature of muscle tissue, which caused demyelination of nerves serving muscles. The gene discussed is ATG13; the disease is infectious mononucleosis.