Interestingly, while evaluating the plasma levels of BECLIN-1 in the viral-onset (N=36 ME/CFS cohort), we observed a robust upregulation of BECLIN-1 from BSL to T2 and T3 stages, suggesting that long-term treatment with rapamycin improves overall autophagy in post-infectious ME/CFS subjects. The gene discussed is BECN1; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.