HLA-DRB1 and cancer: HLA-DRB1 is associated with cervical cancer in Asian, Caucasian, Hispanic or Latin American and black sub-Saharan Africa populations (15).The genetic polymorphism susceptibility of HLA-II genes remains the primary genetic susceptibility in non-infectious malignant tumors such as lung cancer and pancreatic cancer, thereby promoting the maintenance of chronic inflammation and facilitating the evolutionary development of cancer (16).