Our snRNA-seq data also implicates cDC2 cells as principal responders to IFN-γ in IBM, via upregulation of IFN-II-inducible genes, and as activators of CD4+ T cells via specific expression of multiple HLA genes encoding MHC-II, and differential correlation of CD1C with CD4 via RNA-seq. Here, IFNG is linked to inclusion body myositis.