This was in concordance with a subsequent study that showed STING-deficient mice were protected from dopaminergic neuronal loss in the α-syn PFF injection model, highlighting a role for the cGAS-STING and the downstream type-I IFN signalling pathway in driving the PD-associated neurodegeneration (Hinkle et al., 2022). This evidence concerns the gene STING1 and Parkinson disease.