In fully adjusted model which was adjusted with age, gender, bone CT attenuation, BMI, diabetes, creatinine, albumin, AST and LDL-c, the negative association between the AIP and the probability of the vertebral fracture remained statistically significant respectively (aHR = 0.48, 95%CI = 0.26-0.90 for Q2; aHR = 0.41, 95%CI = 0.19-0.88 for Q4). The gene discussed is AIP; the disease is diabetes mellitus.