Fecal microbiota transplantation (FMT) has emerged as a promising treatment that significantly reduces mortality and the need for colectomy, with cure rates reaching upward of 80% in patients with fulminant CDI.4,5 Typically, inflammatory markers such as C-reactive protein (CRP) and white blood cell (WBC) count correlate with disease severity and treatment responsiveness.6,7 However, our case highlights that this relationship is not always straightforward as there was a notable discordance observed between clinical findings and inflammatory markers. This evidence concerns the gene CRP and clostridium difficile infection.