While C. trachomatis may effectively delay NOD2 signaling until late in development by cleaving stem peptides during the natural PG degradative processes associated with its division cycle, this may not significantly impact the production of NOD2-stimulatory PG fragments generated by cellular responses to infection, such as the potential degradation of RBs within lysosomal compartments within hematopoietic cells (Fig. 7). This evidence concerns the gene NOD2 and infection.