PGP and adrenal cortex carcinoma: An ADC targeting the delta-like non-canonical Notch ligand 1 protein, ADCT-701, which has the PDB dimer SG3199 as the payload, was found to be less effective in adrenocortical cancer cell lines and organoids with high expression of P-gp, and the free drug was also reported to be a substrate of P-gp[31].