HLA-DQA1 and celiac disease: We show that Fiber-seq can pinpoint specific genetic variants within the HLA locus that drive disease associations, exposing that the Celiac disease-associated SNP rs9271894 disrupts cooperative TF occupancy at an E-box and adjacent CCAAT box immediately upstream of HLA-DQA1 (Fig. 4h), which is one of the primary immune genes associated with Celiac disease (61).