Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the downregulated genes revealed significant suppression of pathways related to metabolism, lipid handling, and inflammation, including “Lipid and atherosclerosis,” “Fluid shear stress and atherosclerosis,” and “TNF signaling pathway” (Fig. 5C), indicating that ER stress may broadly amplify atherogenic signaling. This evidence concerns the gene TNF and atherosclerosis.