CXCL8 and cystic fibrosis: To determine why let-7b MSC EVs reduced IL-8 secretion, but NC MSC EVs did not in P. aeruginosa exposed CF-pHBEC, we utilized bulk RNA-sequencing to examine the differentially expressed genes (DEGs) in CF-pHBEC treated with P. aeruginosa and let-7b MSC EVs to those treated with P. aeruginosa alone.