Exploring this CGB7-associated downregulation of interferon gamma response genes in both the IMVigor210 cohort dataset and in the TCGA urothelial carcinoma cohort dataset reveals downregulation of numerous genes encoding inflammatory cytokines and chemokines, immune checkpoints such as PD-L1, and HLA proteins involved in antigen presentation; all features of immune evasion in cancer (Figure 3C, 3D). This evidence concerns the gene CD274 and cancer.