Moreover, when we assessed the fraction of remaining DA neurons expressing each of the subtype markers in PD relative to control (Figure 1F) we found stark differences, with a trend toward enrichment of CALB1+ DA neurons (301 +/− 103 %control, unpaired t-test, t=1.9, p=0.10) compared to the significant de-enrichment observed for ALDHA1A1+ DA neurons (41 +/− 12 %control, t=4.9, p=0.002), and especially ANXA1+ DA neurons which were entirely missing in most PD cases (10 +/− 7 %control, Mann-Whitney, U=3.0, p=0.0003). The gene discussed is CALB1; the disease is Parkinson disease.