In contrast, PD-vulnerable Aldh1a1-expressing DA neurons are most abundant in ventral SNc and project to dorsal striatum (Poulin et al. 2018; Wu et al. 2019) Recent mouse studies have identified Anxa1 as subset of Aldh1a1 DA neurons occupying the ventral-most SNc that project densely to dorsal striatum (DS), and as a maker of vulnerable SNc DA neurons in PD-mouse models (Azcorra et al. 2023; Fushiki et al. 2024; Mantas et al. 2024). The gene discussed is ALDH1A1; the disease is Parkinson disease.