Finally, we performed ChIP assay of FOXM1 and found that there was increased FOXM1 bound upstream near the transcription start site of CCNB1 (Figure 7H), suggesting that FOXM1 restores proliferation-differentiation gradient via transcriptional regulation of CCNB1 in EoE (Figure 7I). Here, CCNB1 is linked to eosinophilic esophagitis.