Also, Also, its inhibitory effects chestnut's water extract on some key and metabolic enzymes, including AChE (IC50: 0.084 μg/mL), BChE (IC50: 0.152 μg/mL), and α‐glycosidase (IC50: 0.473 μg/mL) related to diabetes and AD are very important. The gene discussed is BCHE; the disease is Alzheimer disease.